Genome‐wide scan of long noncoding <scp>RNA</scp> single nucleotide polymorphism <scp>s</scp> and pancreatic cancer susceptibility

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic loci, could be instrumental in stratification and implementation prevention strategies. Long noncoding RNAs (lncRNAs) are involved regulation key biological processes, possible role their variability has been unexplored so far. Combining genome wide association studies functional data, we investigated all lncRNAs. We analyzed 9893 PDAC cases 9969 controls identified a genome-wide significant between rs7046076 SNP developing (P = 9.73 × 10−9). This located NONHSAG053086.2 (lnc-SMC2-1) gene allele predicted disrupt binding lncRNA with micro-RNA (miRNA) hsa-mir-1256 that regulates several genes cell cycle, such as CDKN2B. The CDKN2B region pleiotropic its variants have associated human diseases, possibly though an imperfect interaction miRNA. present locus, supported statistical significance plausible mechanism.